Dopamine Receptor Antagonist

Dopamine Receptor Antagonists (102):

Cat. No.	Product Name	Effect	Purity

HY-14541

Olanzapine	Antagonist	99.83%
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic.

HY-135147

ONC206	Antagonist	99.90%
ONC206 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.

HY-B1371

Spiperone	Antagonist
Spiperone is a potent dopamine D2, serotonin 5-HT_1A, and serotonin 5-HT_2A antagonist. Spiperone is a widely used pharmacological tool. Spiperone has the potential for the research of neurology diseases.

HY-N0925

Tetrahydroberberine	Antagonist	98.61%
Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.

HY-101348

L-741626	Antagonist	≥99.0%
L-741626 is a selective D2 dopamine receptor antagonist, with the K_i values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.

HY-B1240

Droperidol	Antagonist	99.90%
Droperidol is a butyrophenone-type Dopamine-2 receptor antagonist.

HY-B1693

Levomepromazine	Antagonist	99.98%
Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors.

HY-14545

Amisulpride	Antagonist	99.92%
Amisulpride is a dopamine D₂/D₃ receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-B1613A

Clebopride malate	Antagonist	99.72%
Clebopride malate is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders.

HY-19654

GSK598809	Antagonist	99.73%
GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pK_i of 8.9.

HY-B1059

Levosulpiride	Antagonist	99.88%
Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class.

HY-116941

A-381393	Antagonist	99.90%
A-381393 is a potent, selective, brain penetrate dopamine D₄ receptor antagonist, with K_is of 1.5, 1.9 and 1.6 nM for human dopamine D_4.4, D_4.2, and D_4.7 receptor, respectively, >2700-fold selectivity over D₁, D₂, D₃ and D₅ dopamine receptors. A-381393 shows moderate affinity for 5-HT_2A (K_i, 370 nM).

HY-B1470

Azaperone	Antagonist	99.68%
Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

HY-19489S

(±)-Levomepromazine-d₆	Antagonist	99.23%
(±)-Levomepromazine-d₆ is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

HY-42849A

Sultopride hydrochloride	Antagonist	99.92%
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.

HY-103093

Zotepine	Antagonist	99.85%
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT_2A, 5-HT_2C, Histamine H₁, α₁-adrenergic and Dopamine D₂ receptors, with K_ds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo.

HY-109150A

Mesdopetam hemitartrate	Antagonist	99.90%
Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (K_i=90 nM; IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease.

HY-129946

Dopamine D2 receptor antagonist-1	Antagonist	99.06%
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.

HY-B0031S1

Quetiapine-d₄ hemifumarate	Antagonist	99.69%
Quetiapine-d₄ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-101382

GR 103691	Antagonist	99.95%
GR 103691 is a potent, selective dopamine D₃ receptor antagonist with a K_i value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D₃ over hD₄ and hD₁ sites.

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